LaLiga Matchday 21 Betting Favorites

Last Updated on January 22, 2026 2:15 pm by Erwin Noguera

A big weekend lies ahead in Spain with Matchday 21 of LaLiga, as Barcelona and Real Madrid battle for the top spot.

The ‘Blaugrana’ will look to hold on to first place when they host Real Oviedo, while the ‘Blancos’ will try to take advantage of any slip-ups but must first face Villarreal.

Atlético Madrid continues their push up the table and will host Mallorca, while Espanyol, one of the surprises of the season, will travel to face Valencia, who have climbed out of the relegation zone.

At Gambyl Exchange, you can explore all the predictions for the LaLiga EA Sports, the final bets for this matchday, and the odds for each match.

LaLiga Weekly Pick Betting Odds

LaLiga Matchday 21: Valencia vs. Espanyol

Valencia arrives motivated for this matchup after a hugely important 0–1 away victory over Getafe that lifted them out of the relegation zone. They now sit 17th with 20 points, just one above Alavés. At home, they are unbeaten in five matches, winning one 1–0 and drawing the other four, all by 1–1 scorelines.

Espanyol have been the big surprise of the season, having gone from battling relegation last year to sitting fifth this time around. They have 34 points and are seven off the Champions League places, but it is also true that seventh-placed Celta are just two points behind, meaning any slip-up could be costly. They are in poor form at the moment, having gone three matches without a win after two home defeats and one away draw.

Valencia vs. Espanyol Betting Pick: Draw

LaLiga Matchday 21: Villarreal vs. Real Madrid

Villarreal is one of the teams making waves this season. They sit in third place with 41 points, eight behind leaders Barcelona, and with one game in hand on everyone else. They are not in their best form, having recorded two wins and five losses in their last seven matches across LaLiga, the Copa del Rey, and the Champions League. They are coming off a 1–2 home defeat to Ajax in the continental competition, which saw them eliminated.

After a difficult few weeks marked by a loss in the Spanish Super Cup final, the departure of Xabi Alonso, and elimination at the hands of Albacete in the Copa del Rey, the team bounced back with a 2–0 win over Levante and a commanding 6–1 victory against Monaco, highlighted by a strong performance from Vinícius, who has been heavily criticized. They are second with 48 points, just one behind Barcelona.

Villarreal vs. Real Madrid Betting Pick: Real Madrid

LaLiga Matchday 21: Atlético Madrid vs. Mallorca

Atlético Madrid sit fourth in the table with 41 points, eight behind leaders Barcelona. They have recorded 12 wins, five draws, and three losses, scoring 35 goals and conceding 17, making them the best defensive side in the league. In LaLiga, they defeated Alavés 1–0, but in the Champions League, they were held to a 1–1 draw by Galatasaray. Julián Álvarez is the team’s top scorer in LaLiga with seven goals, but he has not scored since November 1, and that goal came from the penalty spot. He has now gone nine league matches without finding the net.

As for Mallorca, they sit 15th with 21 points, just two above the relegation zone. They have five wins, six draws, and nine losses, scoring 24 goals and conceding 30. Only Valencia, Levante, and Oviedo have conceded more goals than them. After two straight defeats and three matches without a win, they bounced back with a 3–2 victory over Athletic Club, powered by a hat trick from Vedat Muriqi, who is second in the league’s scoring charts with 14 goals.

Atlético Madrid vs. Mallorca Betting Pick: Atlético Madrid

LaLiga Matchday 21: Barcelona vs. Real Oviedo

Barcelona is leading the league with 49 points, but is only one point ahead of Real Madrid. After 11 straight wins across all competitions and nine in LaLiga, they lost 2–1 to Real Sociedad in a match in which three of their goals were ruled out. They are coming off a 2–4 Champions League victory over Slavia Praha, but lost Pedri to injury.

Real Oviedo are at the bottom of the table with just 13 points after two wins, seven draws, and 11 losses. They have scored only 11 goals in the competition, the worst attacking record, while the 31 goals conceded make them the fourth-worst defense. They are winless in 14 matches, including one in the Copa del Rey, and in their most recent outing, they fell 3–2 to Osasuna.

Barcelona vs. Oviedo Betting Pick: Barcelona