Manchester United vs. Chelsea Preview and Betting Odds

Last Updated on September 19, 2025 11:59 am by Erwin Noguera

Matchday 5 of the Premier League presents Manchester United with another obstacle that could further sink the project of Portuguese manager Ruben Amorim, as they host Chelsea, who are coming off a loss in the Champions League.

United are coming off a crushing 3-0 defeat in the Manchester derby, with goals from Phil Foden and a brace from Erling Haaland.

Although they lost 3-1 to Bayern Munich in the Champions League, in the Premier League, the ‘Blues’ managed a 2-2 draw against Brentford.

Manchester United vs. Chelsea Betting Odds and Info

Why Bet on Manchester United?

Manchester United are going through one of their worst moments in recent history, and the outlook doesn’t seem to be improving, especially as results are opening the door for the departure of Ruben Amorim.

In their last match, the ‘Red Devils’ were humiliated 3-0 in the derby by Manchester City, with goals from Phil Foden and a brace from Erling Haaland.

With this result, United sit in 14th place with just four points. They have scored four goals but conceded seven.

Amorim’s record stands at 31 matches, with eight wins, seven draws, and 16 losses, giving him a win percentage of 25.8%. It’s the worst figure for any manager in the Premier League era.

The Portuguese coach’s exit seems like only a matter of time, and the clash with Chelsea could be his last on the bench that once saw legends like Sir Alex Ferguson and Matt Busby.

Likely, Brazilian forward Matheus Cunha will not feature against Chelsea to avoid risk, meaning the goalscoring responsibility will fall on Benjamin Sesko, who has yet to score his first goal with the team.

Diogo Dalot and Mason Mount are other injury concerns for the squad.

Why Bet on Chelsea?

Chelsea is no longer the powerhouse they were in the previous decade. However, the recovery under Italian manager Enzo Maresca is undeniable, as was demonstrated with last season’s Conference League title.

The ‘Blues’ are coming off a 3-1 defeat to Bayern München in the Champions League, and in the Premier League, they drew 2-2 with Brentford. Goals from Cole Palmer and Moisés Caicedo weren’t enough to secure the win.

The London side sits fifth in the table with eight points, the result of two wins and two draws. They remain unbeaten in the league, scoring nine goals and conceding just three.

Palmer has scored in each of his last two matches, and there’s no doubt he’s one of the most decisive players in English football. It’s worth remembering that last season he finished with 18 goals and 13 assists.

Other players are also continuing to grow, such as Caicedo and Joao Pedro, who have scored five goals since pulling on the London club’s shirt.

The key absence Maresca faces is Liam Delap, who will need at least another week before returning to the pitch.

The only concern Chelsea may face is their youth, not so much for this match against a struggling Manchester United, but when it comes to realistically competing for the Premier League title.

The ‘Blues’ haven’t won at Old Trafford in league play since 2013.

Final Betting Analysis: Manchester United vs. Chelsea

Manchester United may be at home, but they have been a disaster under Ruben Amorim, and they likely are set to suffer another defeat at the hands of a Chelsea side that is regaining its best form and has a difference-maker in forward Cole Palmer.

The numbers at Gambyl Exchange have Chelsea as the favorite with a Moneyline set at +149. Meanwhile, Manchester United is at +180, and the draw is +273.

The last match between these two teams occurred on May 16 of this year, resulting in a victory for Chelsea with a goal from Marc Cucurella (1-0). On the other hand, playing at Old Trafford, Manchester United have 12 games without losing, winning five of them. The last time the ‘Blues’ won as visitors was in 2013.

Go for a win for Chelsea. If you bet $100 at +149, you will gain $149 for a total payout of $249.

Manchester United vs. Chelsea Betting Pick: Chelsea