MLS Conference Cup Semifinals Preview and Betting Odds

Last Updated on November 19, 2025 11:13 am by Erwin Noguera

We have reached the MLS conference semifinals, with eight of the league’s top nine teams facing off. These will be single-elimination matches played at the home stadium of the higher-seeded team from the previous round.

In the West, we find a Canadian team and a debutant. The Vancouver Whitecaps, champions of Canada, will face Los Angeles FC, led by Son, while San Diego FC continues its Cinderella story and will host Minnesota United.

Meanwhile, in the East, thePhiladelphia Union, the best team of the regular season, will face NYC, the lowest-ranked team among those advancing to this stage based on the standings. The other matchup will feature Inter Miami, with Lionel Messi and company, visiting Cincinnati.

At Gambyl Exchange, you can explore all the predictions for the MLS, the final bets for this matchday, and the odds for each match.

MLS Cup Conference Cup Semifinals: Vancouver Whitecaps vs. Los Angeles FC

The Vancouver Whitecaps are having a great season. They tied San Diego for first place in the Western Conference and just eliminated Dallas in two games. Thomas Müller has added valuable experience to a team coming off a championship run in Canada. Brian White, the team’s top scorer, is injured.

Los Angeles finished third in the West. They defeated Austin in both games of the previous series, with a brace from Bouanga and a goal from Son in the second match, the team’s two star players. This year, they were unable to beat the Canadians in their two meetings.

Whitecaps vs. LAFC Betting Pick: Whitecaps

MLS Cup Conference Cup Semifinals: Cincinnati vs. Inter Miami

Cincinnati struggled but managed to advance to the conference semifinals. They needed three games, and in the last one, they came from behind with a brace from Brenner, the second goal coming in the 88th minute. They were not strong at home, earning just 30 out of a possible 51 points.

There is little about Inter Miami that isn’t already well known. They finished third in the East, tied with Cincinnati and one point behind Philadelphia Union. They needed three games to eliminate Nashville, but won the last one 4-0 with braces from Messi and Allende. The Argentine No. 10 is the league’s top scorer (34) and top assist provider (17).

Cincinnati vs. Inter Miami Betting Pick: Inter Miami

MLS Cup Conference Cup Semifinals: Philadelphia Union vs. New York City

The Philadelphia Union were the best team in MLS and came into this round after eliminating the Chicago Fire in two games, one of them decided on penalties. They were the best home team in the league with 40 out of 51 possible points, losing only once at home, to Nashville in March.

As for New York City, they had an excellent road series.

First, they drew and lost on penalties at home, then won both games against Charlotte on the road. They have won six of their last seven away matches.

Philadelphia Union vs. NY City Betting Pick: Philadelphia Union

MLS Cup Conference Cup Semifinals: San Diego FC vs. Minnesota United

San Diego FC were the big surprise of the season, making their MLS debut and winning the Western Conference with 63 points. They won both home games and lost on penalties on the road against Portland. They were a bad home club, winning seven games, drawing five, and losing five.

Minnesota United is the only team in the semifinals that did not win in regulation time. They won twice on penalties at home against the Seattle Sounders. They were one of the best away teams in the league, earning 30 out of 51 possible points, and one of those road victories came against this same opponent.

San Diego vs. Minnesota Betting Pick: San Diego