Leagues Cup Quarterfinals Preview

Last Updated on August 18, 2025 11:29 am by Erwin Noguera

The 2025 Leagues Cup enters its most exciting phase with the quarterfinals, where the best teams from MLS and Liga MX compete. After weeks of intense competition, the tournament has made it clear that the level between the two leagues is increasingly even, and the championship title is within reach of any of the eight qualifiers. With matches promising maximum tension, each game will be a real battle for continental prestige.

The big favorite remains Lionel Messi’s Inter Miami, which, with its hierarchy and the quality of its squad, presents itself as the team to beat. Nonetheless, the history of the Leagues Cup illustrates that nothing is certain, and a single poor performance can alter the outcome for any team. The pressure on the Florida team will be enormous, as everyone wants to defeat the world champion and leave their mark on a tournament that grows in importance year after year.

The rest of the qualifiers arrive with solid arguments to dream big. Tigres and Toluca represent the experience and offensive power of Liga MX, while Pachuca and Puebla seek to surprise with their intensity and freshness. On the MLS side, Orlando City and Seattle Sounders have shown consistency and a defined style of play. However, LA Galaxy, with its history and star players, wants to return to being an international contender. With this landscape, the quarterfinals promise exciting soccer and more than a few surprises on the road to the title.

At Gambyl Exchange, you can explore all the predictions for the Leagues Cup, the final bets for this Matchday, and the odds for each match.

Leagues Cup Quarterfinals: Inter Miami vs. Tigres

Chase Stadium will host the most anticipated match of the quarterfinals: Inter Miami vs. Tigres. Javier Mascherano’s team comes in second in the standings with eight points, driven by Messi’s magic and the addition of Rodrigo De Paul, a midfielder who brings balance and creativity to the team.

Playing at home gives the “Garzas” an important advantage. Although the opponent is no pushover, Tigres is a team accustomed to high-pressure situations, and with reinforcements such as Ángel Correa, their attack seems revitalized.

Guido Pizarro’s team, third in the standings with 6 points, knows that the pressure will be on the pink club. The felines will look to play a smart game, with compact blocks and quick transitions, to counter Inter’s possession.

Tigres’ international experience often plays a crucial role. This time, they must contend with a challenging environment and the pressure of Messi, who appears determined to win yet another title.

The home field advantage and Miami’s offensive power tip the scales in favor of the Florida team, although a close match is expected, with details that could determine the outcome. We predict that Inter Miami will win.

Inter Miami vs. Tigres Betting Pick: Inter Miami

Leagues Cup Quarterfinals: Toluca vs. Orlando City

Dignity Health Sports Park will host the clash between Toluca and Orlando City, a match that pits the reigning Mexican soccer champions against a rival looking to cause an upset.

The “Red Devils” arrive after eliminating New York City FC in a solid performance and boast one of the most balanced squads in the competition, with players such as Jesús Angulo and Paulinho in great form. Antonio Mohamed’s team not only has depth but is also accustomed to competing with intensity in international tournaments.

Orlando City, for its part, comes into this match with the hope of causing an upset. Martín Ojeda leads the attack, accompanied by internationally renowned players such as Luis Muriel, Marco Pasalic, and goalkeeper Pedro Gallese, giving the team offensive options and security between the posts. However, the odds reflect that the Americans are clear underdogs against a Toluca side that looks more solid across all lines.

The odds confirm Toluca’s favoritism, although Orlando could cause problems if it manages to cut off the midfield and take advantage of spaces on the counterattack.

Toluca vs. Orlando City Betting Pick: Toluca

Leagues Cup Quarterfinals: Seattle Sounders vs. Puebla

Lumen Field will host a clash with a very clear outcome: Seattle Sounders vs. Puebla. The American team was the best in the initial phase, earning 9 points and winning all three of its games in regulation time.

With an experienced squad and a consolidated style of play, the Sounders are one of the big favorites not only for the game but also for the title. Their ability to apply high pressure and their offensive strength have been decisive.

On the other side, Puebla arrives with much merit, qualifying at the last minute thanks to Juárez’s defeat. Although they earned 6 points and showed character in the previous phase, they now face an opponent that, on paper, looks far superior. The “Franja” will rely on tactical discipline and defensive resistance, hoping to find an isolated opportunity to surprise.

Unless there is a miracle or a perfect game plan from Puebla, everything points to the MLS team taking the victory and advancing to the semifinals. As a result, our winner is the Sounders.

Seattle Sounders vs. Puebla Betting Pick: Seattle Sounders

Leagues Cup Quarterfinals: LA Galaxy vs. Pachuca

The last quarterfinal match will have a special flavor: LA Galaxy vs. Pachuca at Dignity Health Sports Park.

The Los Angeles team, despite an inconsistent season in the MLS, found its best form in the Leagues Cup, scoring 10 goals in 3 games, and with players such as Joseph Paintsil, Matheus Nascimento, and Marco Reus in top form. They also have the advantage of playing at home and the momentum of being the defending MLS Cup champions.

Pachuca, however, arrives in solid form and with the confidence gained from competing in the Club World Cup. The Tuzos are coming off a victory over San Diego FC in a match with special significance for Chucky Lozano and have shown their ability to respond in big games. Players such as Jhonder Cádiz and Daniel Aceves have been key to their performance, while the midfield provides balance.

LA Galaxy vs. Pachuca Betting Pick: Pachuca