Apertura MX 2025: Matchday 12 Betting Favorites

Last Updated on October 1, 2025 2:13 pm by Erwin Noguera

We have reached Matchday 12 of the Apertura MX, and the competition for a spot in the playoffs intensifies, especially for those aiming to finish in the top six.

Toluca and Monterrey share first place with 25 points, and both will have tough away games this weekend, as the former will visit León and the latter will travel to Tijuana.

América, one point behind, will be keeping an eye as they host Santos, while Tigres will face Cruz Azul in the most interesting matchup.

At Gambyl Exchange, you can explore all the predictions for the Liga MX Apertura MX 2025, the final bets for this Matchday, and the odds for each match.

Apertura MX 2025 Weekly Picks Betting Odds

Apertura MX 2025 Matchday 12: Tigres vs. Cruz Azul

Tigres cannot afford to relax. With 22 points, they are in fifth place in the tournament after winning six games, drawing four, and losing one. They have scored 21 goals, although seven of those came against Puebla. With nine goals conceded, they have the best defense in the tournament. They are on a seven-game unbeaten run in which they drew four, but have won the last two. During that stretch, in four of those games, the home team received a red card.

On Cruz Azul’s side, it could be said they are at their lowest point. They have 24 points, sitting in fourth place, but are coming off a 2-0 loss to Tijuana, suffering their first defeat of the tournament. Before that, they had drawn at home against Querétaro, second-to-last in the table, ending a streak of seven straight wins. In three of their last four matches, they received a red card.

Tigres vs. Cruz Azul Betting Pick: Draw

Apertura MX 2025 Matchday 12: León vs. Toluca

León has been one of the disappointments so far this season. Despite having great players, they are in 11th place with 12 points, currently out of the playoffs. They have three wins, three draws, and five losses, scoring 10 goals (the second-worst attack) and conceding 18. They have only managed two of the last 12 points, and at home, they earned eight of their 12 total points.

On Toluca’s side, they are looking down on everyone from the top. They have 25 points after eight wins, one draw, and two losses, scoring 31 goals and conceding 14, giving them a +17 goal difference. They are on a five-game winning streak in which they scored at least three goals in every match, although it’s also true that they only kept a clean sheet in one of those. Paulinho is second on the scoring chart with seven goals, while Alexis Vega leads in assists with seven, and Nicolás Castro is second with five.

León vs. Toluca Betting Pick: Toluca

Apertura MX 2025 Matchday 12: América vs. Santos

América is in third place in the tournament, one point behind the leaders, with seven wins, three draws, and one loss. They have scored 23 goals and conceded 11, making them the second-best defense in the league. After a short slump, they have two straight wins, the latest a 4-1 victory over Pumas with a brace from Alejandro Zendejas, who now has five, and in the last five matches, he has either scored or assisted.

On Santos’ side, it has been another very poor tournament, and they are outside the playoff spots. They sit 13th with 10 points from three wins, one draw, and seven losses. They are coming off a 1-0 defeat to Monterrey and have only earned one of 15 points as visitors. In their last two games, they have seen red cards, meaning Anthony Lozano will not be available this Saturday.

América vs. Santos Betting Pick: América

Apertura MX 2025 Matchday 12: Tijuana vs. Monterrey

Tijuana has been one of the surprises of the tournament and is currently in sixth place, qualifying directly for the playoffs for now. They have 19 points after five wins, four draws, and two losses, scoring 21 goals and conceding 11. They are coming off ending Cruz Azul’s unbeaten run, defeating them 2-0 in Jesús Corona’s farewell, and are the best home team in the tournament with four wins and two draws.

Monterrey sits in second place, tied on points (25) with Toluca but with a worse goal difference (21 scored and 17 conceded). The Rayados went through a rough patch, managing only one of six points and suffering a 6-2 loss against the ‘Diablos Rojos’, but bounced back with a 1-0 win over Santos. While they have earned 12 of 18 points as visitors, they have conceded more goals (12) than they have scored (11).

Tijuana vs. Monterrey Betting Pick: Draw