Last Updated on September 15, 2025 11:10 am by Erwin Noguera
Week 3 of the NFL kicks off this Thursday with Thursday Night Football, as the Buffalo Bills host the Miami Dolphins in an AFC West matchup.
The Bills are off to a perfect start, coming off a dominant 30-10 road win over the New York Jets to make it two straight victories.
The Dolphins, on the other hand, have only known the bitter taste of defeat this season, with their most recent loss coming at home against the New England Patriots.
Buffalo Bills vs. Miami Dolphins Betting Odds and Info
| When? | Thursday, September 18, 8:15 pm ET, 7:15 pm CST, 6:15 pm MT, and 5:15 pm PT |
| Where? | Highmark Stadium |
| What are the Odds for the Bills? | -847 |
| What are the Odds for the Dolphins? | +575 |
| What is the Over/Under? | 48.5 |
| Where Can I Watch it? | Prime Video |
Why Bet on Bills?
The Buffalo Bills are title contenders, and they’ve shown it at the start of this season. First, they pulled off a nail-biting 41-40 win over the Baltimore Ravens with a game-winning field goal, and this past weekend they crushed the New York Jets at MetLife Stadium, 10-30.
It wasn’t Josh Allen’s best night, but he got the job done, especially on the ground. The quarterback attempted 25 passes, completing 14 for 148 yards, with no touchdowns, no interceptions, and just one sack for a one-yard loss. He also had six carries, including a 40-yard run, for a total of 59 rushing yards.
The Bills’ scores came on the ground. The star of the game was James Cook, who had 21 carries for 132 yards and two touchdowns in the first and second quarters. He became the first Bills RB to score rushing touchdowns in six straight regular-season games since 1988.
The other touchdown was scored by wide receiver Elijah Moore, his first since arriving from the Cleveland Browns.
On defense, the team recorded four sacks, and A.J. Epenesa recovered a fumble.
Why Bet on Dolphins?
The Miami Dolphins finished last NFL season with a losing record of 8-9, and this year they were hoping to turn that image around and at least fight for a Wild Card spot. However, their start hasn’t gone as planned, and they’re already 0-2.
First, they were crushed on the road by the Indianapolis Colts, 33-8, and then they were upset at home by the New England Patriots, 27-33.
Despite the result, it was a strong game from quarterback Tua Tagovailoa, who posted an 81% completion rate with 26 completions on 32 attempts, for a total of 315 yards and two touchdowns—one to running back Devon Achane and the other to wide receiver Jaylen Waddle. On the negative side, he had one interception and was sacked five times.
On the defensive side for Miami, the standout was linebacker Tyrel Dodson with nine tackles, while the unit as a whole registered three sacks.
Last season, the Dolphins won just three of their nine road games.
Final Betting Analysis: Bills vs. Dolphins
It will be a matchup between direct rivals in the AFC East; however, the gap between the Bills and the Dolphins is huge, and the results have shown it, which is why we believe Buffalo will win comfortably.
The numbers at Gambyl Exchange have the Bills as the favorite, with their Moneyline at -847, while the Dolphins are at +575.
The last time they faced each other was on November 3, 2024, with the Bills winning 30-27 thanks to a field goal with five seconds left in a great battle between Allen and Tagovailoa. Buffalo is on a six-game winning streak in this matchup, with the Dolphins not winning since 2022 and not winning on the road since 2016.
Go for a win for the Bills in the Moneyline. If you bet $100 at -847, you will gain $12 for a total payout of $112.
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