Kansas City vs. Los Angeles Preview and Betting Odds

Last Updated on September 3, 2025 4:04 pm by Erwin Noguera

The 2025 NFL regular season kicks off with a blockbuster international showdown: the defending AFC West Champion Kansas City Chiefs clash with division rivals Los Angeles Chargers in Sao Paulo, Brazil.

The Chiefs are entering this matchup with confidence, thanks to their favorable history against the Chargers. They are likely eager to make the most of the opportunity to play in a different country.

On the other hand, the Los Angeles team has shown significant improvement under the leadership of Justin Herbert. They are expected to focus on starting their season strong.

As both teams prepare to face off in a different country, this matchup promises to be exciting for NFL fans everywhere. Let’s dive in as we approach the kickoff of Week One in this thrilling new NFL season.

At Gambyl Exchange, you can explore all the predictions for the NFL, the final bets for this matchday, and the odds for each match.

Kansas City vs. Los Angeles Betting Odds and Info

Why Bet on the Kansas City Chiefs?

Entering their 2025 campaign, the Chiefs aim to win their 10th consecutive AFC West title by taking down a familiar opponent on international turf. Their revamped offensive line and lockdown defense under Steve Spagnuolo are key elements. This game offers a prime opportunity to establish momentum.

Kansas’s consistency and dominance over the Chargers in recent seasons give them a clear edge even in a neutral, international setting.

As the team heads into a different country to face their opponents, they are likely feeling confident and eager to kick off the season. Patrick Mahomes remains determined to prove himself as one of the greatest of all time.

Why Bet on the Los Angeles Chargers?

Under head coach Jim Harbaugh, the Chargers look to rebound by leveraging their improved offensive depth, featuring running back Najee Harris, rookie Omarion Hampton, and receiver Tre Harris. Despite their strong defense from last year, they’ll face a Chiefs team eager to assert dominance.

However, a win over the Chiefs could send a statement, and it could be just what Justin Herbert needs to kick-start the next step in his career.

This match will showcase how good things are looking for the Chargers’ offense.

Final Betting Analysis: Chiefs vs. Chargers

The upcoming match in Brazil is shaping up to be quite intriguing. However, we believe the outcome will maintain the Chiefs’ consistency, allowing them to secure their eighth consecutive victory over the Chargers.

At Gambyl Exchange, we can see that there is a Moneyline that favors the Chiefs at -167, while the Chargers start at +150.

It’s not like the Chargers won’t be competitive here, but we don’t believe they will keep the pace the Chiefs will bring to the match.

Look for a win for the Chiefs. If you put $100 at -167, you’ll see a $59.88 win with a total payout of $159.88.

Chiefs vs. Chargers Betting Pick: Chiefs