NFL Wild Card: Jaguars vs. Bills Betting Odds and Preview

Last Updated on January 9, 2026 2:20 pm by Erwin Noguera

The NFL gives us a very evenly matched series in the AFC Wild Card round as the Jacksonville Jaguars host the Buffalo Bills.

The Jaguars were one of the surprises of the season and arrived in great form, coming off a dominant 41–7 win over the Tennessee Titans in their final game.

Meanwhile, the Bills come in motivated after a strong regular season, which they capped off with a 35–8 victory over the New York Jets.

At Gambyl Exchange, you can explore all NFL predictions, the final bets for this Matchday, and the odds for each match.

Jacksonville Jaguars vs. Buffalo Bills Betting Odds and Info

Why Bet on Jaguars?

The Jacksonville Jaguars surprised many with a 13–4 season, capturing the AFC South title and finishing third in the conference behind the Denver Broncos and the New England Patriots, both of whom posted 14–3 records.

The Jaguars enter this Wild Card matchup riding an eight-game winning streak, holding opponents under 10 points on three occasions during that run. It is their first postseason appearance in three years, since their loss to the Kansas City Chiefs in the Divisional Round.

They come in highly motivated after crushing the Tennessee Titans 41–7 in the final week. Trevor Lawrence enjoyed his best season in terms of scoring, throwing 29 touchdown passes and adding nine more on the ground. He completed 341 of 560 passes for 4,007 yards, a 60.9% completion rate, while being intercepted 12 times and sacked 41 times. He failed to score in just one game all season.

Travis Etienne Jr. was the most impactful player on offense, leading the team in receiving touchdowns and finishing second in rushing scores behind Lawrence. He recorded six receiving touchdowns on 36 catches and added seven rushing touchdowns on 260 carries.

Wide receiver Parker Washington also stood out, posting 58 receptions for 847 yards and five touchdowns.

Defensively, the standout performer was linebacker Foyesade Oluokun, who totaled 143 tackles (69 solo and 74 assisted), along with one sack and one interception.

Overall, the Jaguars ranked fifth in the league in total touchdowns with 55, including 29 through the air and 22 on the ground.

Why Bet on Bills?

The Buffalo Bills’ mission is to improve on last season’s performance, when they fell in the Conference Championship to the Kansas City Chiefs by a 32–29 score. This year, they finished sixth in the conference with a 12–5 record after the New England Patriots claimed the division at 14–3.

They are coming off a 35–8 win over the New York Jets, using mostly backups, and have won five of their last six games. Josh Allen wrapped up the regular season completing 319 of 460 passes for a 69.3% completion rate, 3,668 yards, 25 passing touchdowns, and 14 rushing touchdowns, just one shy of his best season in 2023.

The Bills are the second-highest scoring team in the NFL with 62 total touchdowns, trailing only the Los Angeles Rams (65). Their 30 rushing touchdowns lead the league. On the ground, Allen (14) and James Cook (12) stand out, combining for 26 of the team’s 30 rushing scores, with Ty Johnson adding three more and Elijah Moore one.

Cook leads the NFL in rushing yards with 1,621 on 309 carries, averaging 5.2 yards per carry. As shown, the strength of this team lies in its ground game, and that is something they will look to exploit.

Final Betting Analysis: Jaguars vs. Bills

The Bills have shown they are a very strong team on the ground, but the Jaguars boast one of the league’s best defenses, and that is something they will look to impose, along with a great Trevor Lawrence, who will lead Jacksonville to a victory.

The numbers at Gambyl Exchange list the Bills as the favorites, with their Moneyline at -115, while the Jaguars are priced at -105.

The last time these two teams faced each other was on September 23, 2024, when the Bills won 47–10 with four touchdown passes from Josh Allen. In Jacksonville, the home team has won three straight games against this opponent, including a playoff matchup, and has not lost since 2013. The all-time series is tied at 10–10.

Go for a win for the Jaguars. If you bet $100 at -105, you will gain $95 for a total payout of $195.

Jaguars vs. Bills Betting Pick: Jaguars