Patriots vs. Giants for MNF Preview and Free Pick

Last Updated on November 28, 2025 3:46 pm by Erwin Noguera

This Monday Night Football brings us a very uneven matchup, with the best team in the NFL, the New England Patriots, hosting the second-worst team in the league, the New York Giants.

The Patriots are on a great run and are coming off a 20–26 road win over the Cincinnati Bengals. Meanwhile, the Giants remain in one of their worst skids and fell in overtime to the Detroit Lions, 34–27.

At Gambyl Exchange, you can explore all the predictions for the NFL, the final bets for this Matchday, and the odds for each match.

New England Patriots vs. New York Giants Betting Odds and Info

Why Bet on Patriots?

The New England Patriots went from being near the bottom of the NFL to leading the league.They hadn’t had a winning season since 2021, when they finished 10–7. Now they are 10–2, and they will almost certainly surpass that mark.

They are coming off a 20–26 road win against the Cincinnati Bengals and have now won nine straight games. Drake Maye finished with 22 completions on 35 attempts for 294 yards, one touchdown pass, one interception, and one sack.

Maye ranks third this season in passing yards (3,130), behind Dak Prescott and Patrick Mahomes; fourth in completions (252); fifth in touchdown passes (21); and, among quarterbacks with more than 50 attempts, he leads the league in completion percentage (71%) and is second in yards per attempt (8.8).

Tight end Hunter Henry was the receiver on Maye’s touchdown pass, while defensive back Marcus Jones intercepted a pass and returned it 33 yards for a score. It was his third interception of the season and his second touchdown, after scoring one in Week 4 on a punt return.

Rookie Venezuelan kicker Andrés Borregales also stood out, converting four field goals, the most of his young career. His 14 points were also a personal best and earned him the AFC Special Teams Player of the Week award.

Why Bet on Giants?

Last season for the New York Giants was an embarrassing failure, and this year appears to be heading down the same path.They finished last year with a 3–14 record, and now they sit at 2–10, almost identical.

They are coming off an overtime loss to the Detroit Lions, 34–27, and have now dropped six straight games. They also haven’t won on the road since October 6, 2024, making it 12 consecutive away matches without a victory.

This is the second time this season they have lost in overtime. Earlier in the year, the Cowboys tied the game with a last-second field goal before beating them in the extra period. Now, it was another field goal, this time with 28 seconds left.

That day, Jameis Winston returned as the starting quarterback and played reasonably well, completing 18 of 36 passes for 366 yards, two touchdowns, one interception, and one sack. He also scored once as a receiver on a trick play from wideout Gunner Olszewski. Despite that performance, rookie Jaxson Dart has cleared concussion protocol and returned to practice, so he is expected to start again.

Dart has appeared in nine games, completing 128 of 204 passes for a 62.7% completion rate, 1,417 yards, 10 passing touchdowns, 7 rushing touchdowns, three interceptions, and 21 sacks.

Against the Lions, they couldn’t hold on to their lead—they were up 17–27 with 11 minutes left—and failed to stop Jahmyr Gibbs, who scored two rushing touchdowns and one receiving touchdown against them.

Final Betting Analysis: Patriots vs. Giants

When the best team in the league, riding a nine-game winning streak, faces one of the worst teams in the league, on a six-game losing streak, and the game is at the leader’s home stadium, there isn’t much more to add. The Patriots are having a fantastic season, and we don’t believe the Giants will be any sort of obstacle for them.

The numbers at Gambyl Exchange have the Patriots as the favorite, with a Moneyline of -350, while the Giants are listed at +275.

The last time these two teams faced each other was on November 26, 2023, when the Giants won 10–7, while the previous meeting in New England was in 2019, with the Patriots winning 35–14. The all-time series between the two is tied 7–7, including two Super Bowls won by the Giants.

Go for a win for the Patriots. If you bet $100 at -350, you will gain $29 for a total payout of $154.

Patriots vs. Giants Betting Pick: Patriots