Seahawks vs. 49ers Free Pick and Betting Odds

Last Updated on January 16, 2026 12:43 pm by Erwin Noguera

In a major matchup between two NFC West rivals, the Seattle Seahawks and the San Francisco 49ers will determine one of the conference finalists.

The Seahawks come in fully rested after finishing first in the conference and advancing directly to this round.

The 49ers, meanwhile, pulled off one of the biggest surprises by eliminating the defending champions, the Eagles, in Philadelphia.

At Gambyl Exchange, you can explore all NFL predictions, the final bets for this Matchday, and the odds for each match.

Seattle Seahawks vs. San Francisco 49ers Betting Odds and Info

Why Bet on Seahawks?

The Seattle Seahawks arrive motivated on all fronts. They finished first in their conference, are far more rested than their opponent, are playing at home, and have no major injuries.

The Seahawks closed the regular season with a 14–3 record, clinching the divisional title and the top seed in the conference in Week 18 by beating the 49ers (12–5) in San Francisco, 3–13. Everything was on the line, and Seattle delivered. They come in on a seven-game winning streak.

Not only did they beat their rival, but they also limited them to just a field goal, held Brock Purdy to only 127 passing yards, and allowed just 53 rushing yards. They showed they are a dominant defense, and that will once again be their main weapon, although head coach Mike Macdonald said they will show something completely different from that game.

Sam Darnold finished the regular season completing 323 of 477 passes for 4,048 yards, with 25 touchdown passes and 14 interceptions—a fairly high total, surpassed only by Geno Smith (17) and Tua Tagovailoa (15). It is something to keep in mind.

On an individual level, one of the standout performers was Jaxon Smith-Njigba. The wide receiver led the team with 1,793 receiving yards on 119 receptions, averaging 15.1 yards per catch and scoring 10 touchdowns.

Linebacker Ernest Jones missed this week due to illness, but is expected to recover. He is one of the most important defensive players, leading the team with 126 combined tackles.

Why Bet on 49ers?

The San Francisco 49ers have already landed the first blow and are now looking to strike again. After eliminating the defending NFL champions, the Philadelphia Eagles, on the road, they now set their sights on the No. 1 seed in the NFC.

It was a great game in which they won 19–23 thanks to a Christian McCaffrey touchdown with just under three minutes remaining. The running back was key with two touchdowns, both through the air in the fourth quarter. Brock Purdy completed 18 of 31 passes for 262 yards, with two touchdown passes and two interceptions, while wide receiver Jauan Jennings even threw a touchdown pass.

When it comes to Purdy, although he has thrown 13 touchdown passes over his last five games, the reality is that he has 10 interceptions in nine games this season. He has been intercepted in four consecutive games, and it also happened in both meetings against the Seahawks this season, where he was picked off three times.

On the other side, there is Christian McCaffrey. Now fully recovered from the injury that sidelined him for most of 2024, he has shown this season that he is one of the best at his position in the league. During the regular season, he totaled 1,202 yards on 311 carries with 10 rushing touchdowns, along with 924 yards on 102 receptions and seven receiving scores, in addition to what he produced against the Eagles.

The bad news for Kyle Shanahan is the injury to his star tight end George Kittle, who will miss the remainder of the season.

Final Betting Analysis: Seahawks vs. 49ers

It should be a great matchup, a tight one as we saw during the regular season, with narrow victories. We believe the 49ers arrive tired after their Wild Card round game and with one less day of rest since the game is on Saturday, while the Seahawks come in more motivated by their strong finish to the season, by playing at home, and by the most recent meeting between the two, so we believe they will take the win.

The numbers at Gambyl Exchange list the Seahawks as the favorites, with their moneyline at -360, while the 49ers are priced at +280.

The last time they faced each other was on January 3 of this year, with the Seahawks winning 3–13. However, the last time they played in Seattle was on September 7, 2025, when the 49ers won 13–17, and at Lumen Field, San Francisco has won their last four visits.

Go for a win for the Seahawks. If you bet $100 at -360, you will gain $28 for a total payout of $128.

Seahawks vs. 49ers Betting Pick: Seahawks