Seahawks vs Cardinals for TNF Betting Odds and Free Pick

Last Updated on September 22, 2025 3:43 pm by Erwin Noguera

Week 4 of the NFL kicks off with Thursday Night Football, featuring a direct NFC West clash as the Arizona Cardinals host the Seattle Seahawks.

The Cardinals just suffered their first loss of the season, and it couldn’t have come in a worse way than a 16-15 defeat against their biggest rivals in the division, the San Francisco 49ers.

On the other side, the Seahawks showed no mercy as they crushed the New Orleans Saints 44-13.

Arizona Cardinals vs. Seattle Seahawks Betting Odds and Info

Why Bet on Cardinals?

The Arizona Cardinals had a strong start to the season with two victories, away against the Saints and at home versus the Panthers. However, this weekend they suffered their first setback, and it came against their main division rival: the San Francisco 49ers.

It was a 16-15 win sealed by an Eddy Pineiro field goal on the final play. The Cardinals had taken the lead thanks to a safety with just over three minutes remaining, but the victory slipped away at the end.

Kyler Murray had a solid outing, completing 22 of 35 passes for a 63% completion rate. He threw for 159 yards and one touchdown, caught by tight end Trey McBride.

Chad Ryland missed one of his three field goal attempts, while on defense, second-year defensive back Dadrion Taylor-Demerson recorded his first career NFL interception. In the same unit, defensive end Josh Sweat notched the team’s only sack.

The devastating news for Jonathan Gannon is that running back James Conner, who had scored in the first two games, suffered a right ankle injury and will miss the entire season. Coming off back-to-back 1,000-yard seasons, his absence is a huge blow to the offense. Second-year back Trey Benson is expected to step into his role.

Why Bet on Seahawks?

The Seattle Seahawks improved to a 2-1 record after a dominant 44-13 victory over the New Orleans Saints.

It was an excellent game for Sam Darnold, who needed only 14 completions on 18 attempts to rack up 218 yards and two touchdowns, caught by wide receivers Jaxon Smith-Njigba and Tory Horton.

Horton, a rookie out of Colorado State, also delivered a spectacular 89-yard kickoff return for a touchdown. He now has three touchdowns this season.

On the ground, Kenneth Walker III stood out with two touchdowns on 16 carries, totaling 38 yards.

The Seahawks exploded early, putting up 21 points in the first quarter and 17 more in the second, for a massive 38-point first half.Jason Myers contributed with three field goals and five extra points, finishing with 14 points.

Defensively, Derion Kendrick grabbed an interception, while quarterback Spencer Rattler was sacked twice.

Final Betting Analysis: Cardinals vs. Seahawks

Great matchup between two teams tied with a 2-1 record in the NFC West. The Cardinals are coming off a painful defeat and a tough injury loss, while the Seahawks arrive highly motivated, and we believe that’s why they’ll take the win.

The numbers at Gambyl Exchange have the Cardinals as the favorite, with their Moneyline at -120, while the Seahawks are listed at -110.

The last time these two teams met was on December 8, 2024, with the Seahawks winning on the road 18-30. Seattle is now on a seven-game winning streak in this matchup, while the Cardinals haven’t beaten them since 2021.

Go for a win for the Seahawks in the Moneyline. If you bet $100 at -111, you will gain $91 for a total payout of $191.

Cardinals vs. Seahawks Betting Pick: Seahawks