Premier League Matchday 6 Betting Favorites

Last Updated on September 25, 2025 9:16 am by Erwin Noguera

We’ve reached Matchday 6 of the Premier League, and it’s shaping up to be a weekend packed with exciting games featuring the league’s main contenders.

Let’s start with the leaders, Liverpool, who will face a tough visit against Crystal Palace, the same rival that beat them in the Community Shield.

Arsenal, meanwhile, will travel to face a strong Newcastle side, now without Aleksander Isak and struggling with a poor start to the season. Their neighbors, Tottenham, will host bottom-placed Wolverhampton, who have yet to earn a single point.

Lastly, Pep Guardiola’s Manchester City will have a home assignment against one of the league’s weakest teams, Burnley.

At Gambyl Exchange, you can explore all the predictions for the Premier League, the final bets for this matchday, and the odds for each match.

Premier League Weekly Picks Betting Odds

Premier League Matchday 6: Manchester City vs. Burnley

Manchester City sits in mid-table with two wins, one draw, and one loss, scoring nine goals and conceding five. They’re coming off a draw in London against Arsenal after a Gabriel Martinelli goal in the 90+3 minute. Erling Haaland scored for the ‘Citizens’ and now has six goals, leading the league’s scoring charts. The Norwegian has 13 goals in eight matches this season, including the five he scored against Moldova with his national team. During the week, they also played in the third round of the EFL Cup, defeating Huddersfield 0-2.

Burnley sit in 16th place with one win, one draw, and three defeats. They’re coming off a 1-1 home draw versus Nottingham Forest, and their two previous matches were both one-goal losses, each conceded in stoppage time. They also played in the EFL Cup midweek but couldn’t advance, losing 1-2 at home to Cardiff.

Manchester City vs. Burnley Betting Pick: Manchester City

Premier League Matchday 6: Crystal Palace vs. Liverpool

Crystal Palace is one of only two unbeaten teams in the league, sitting fifth with nine points. With just two goals conceded, they boast the best defense in the competition, and they kicked off this season by winning the Community Shield against this same opponent. They’re coming off a 1-2 away win over West Ham.

Liverpool is the other unbeaten side, though they hold a perfect record with five wins in five matches. They arrive motivated after winning the Merseyside Derby 2-1 against Everton, although Arne Slot’s team hasn’t looked like the dominant machine of the past. Across the Premier League, Champions League, and EFL Cup, only one of their seven wins has been by more than a single goal—and that was by two, versus Bournemouth, with goals in the 88th and 90+4 minutes.

Crystal Palace vs. Liverpool Betting Pick: Draw

Premier League Matchday 6: Tottenham vs. Wolverhampton

A very good start for Tottenham, who sit third with 10 points after three wins, one draw, and one loss. In their last league match, they managed a 2-2 draw away at Brighton, and during the week, they had no trouble beating Doncaster 3-0 in the EFL Cup. The ‘Spurs’, however, are dealing with several key injuries.

Nobody expected this kind of season from the Wolves. Five matches, five defeats, conceding 12 goals and scoring only three. They are now winless in eight straight league games, with seven losses in that stretch. The only bright spot is their EFL Cup run, where they’ve won both matches, including Tuesday’s 2-0 victory over Everton.

Tottenham vs. Wolverhampton Betting Pick: Tottenham

Premier League Matchday 6: Newcastle vs. Arsenal

Newcastle have not had the start to the season they were hoping for. With six points, they sit 13th in the table with one win, three draws, and one loss, scoring just three goals and conceding the same amount. They are coming off a goalless draw against Bournemouth, but during the week, they beat Bradford 4-1 in the EFL Cup thanks to braces from Joelinton and William Osula.

Arsenal are determined to finally win a league title after more than 20 years and three straight second-place finishes. For now, though, they find themselves in the same spot: second. They have 10 points after three wins, one draw, and one loss, with 10 goals scored and only two conceded, giving them the second-best attack and the best defense in the league. They are coming off a last-minute equalizer against Manchester City (1-1) thanks to a stunning strike from Martinelli, and also defeated Port Vale 0-2 in the EFL Cup.

Newcastle vs. Arsenal Betting Pick: Arsenal