Last Updated on September 19, 2025 4:48 pm by Erwin Noguera
The Derby della Capitale returns with Lazio hosting Roma in Matchday 4 of the Italian Serie A. The rivalry is intense, and both sides have reasons to feel the weight of expectations.
Lazio aims to show resilience despite a list of absences, while Roma is trying to maintain their recent edge in this fixture under new leadership.
Lazio, currently in 12th place, will host this matchup. They have been struggling to find their rhythm, having lost both their opening match and their latest game, although they managed to secure an easy victory in between. This inconsistent performance does not inspire much confidence.
On the other hand, Roma, positioned 6th in the standings, will be the visiting team. They come into this clash with two wins that have helped kickstart their campaign, but they recently suffered a 1-0 defeat in their latest match.
Lazio vs. Roma Betting Odds and Info
| Lazio +189 | Roma +167 | Draw Offs: +238 |
| When? | Sunday, September 21st, 6:30 am ET, 5:30 am CST, 4:30 am MT, and 3:30 am PT |
| Where? | the Stadio Olimpico |
| Where Can I Watch it? | Paramount+ and Star+ |
Why Bet on Lazio?
Lazio will be forced to cope with several absences. Key players such as Manuel Lazzari, Matias Vecino, Niccolo Rovella, Patric, Samuel Gigot, and striker Valentin Castellanos are all unavailable due to injuries.
This weakens both their defensive stability and attacking options significantly. In particular, losing Gigot in defense and Castellanos up front reduces their ability to apply pressure in the final third.
Despite this, Lazio can still pose a threat. Players like Mattia Zaccagni and Toma Basic have shown good form, and symbolically, playing at the Olimpico gives them home support that often helps in tight derbies. If they can stay compact, manage the midfield battles, and avoid early goals, Lazio has the chance to make Roma earn everything. Their style, when forced into a lower block plus counterattack, could frustrate Roma if the latter start aggressively.
Why Bet on Roma?
Roma are dealing with fewer absentees: Leon Bailey and Paulo Dybala are sidelined through injury. While losing Dybala is a blow, Roma have more depth in wide areas and healthier attacking options. Evan Ferguson is expected to feature, likely getting a start, which provides energy and fresh legs.
Under their new manager, Roma have built momentum. They won their first two matches of the Serie A season but dropped points in their most recent league outing. Still, their performances have shown signs of cohesion, especially in defense. Rome derbies have historically been tight, often decided by small margins, discipline, or moments of individual skill, which is more likely given Lazio’s depleted squad.
Final Betting Analysis: Lazio vs. Roma
We believe that once the match begins, both teams will give their all against their fierce local rivals. Despite Lazio’s shaky start to the season, we think they can secure at least a point in this game.
The numbers at Gambyl Exchange have Roma listed as the favorite, with a moneyline of +167; meanwhile, Lazio has odds of +189, and the draw is set at +238.
This fixture has recorded the highest number of cards in Serie A this century, so maintaining composure will be crucial. It will be interesting to see how the passionate coaches, Sarri and Gasperini, handle the pressure.
In the end, we expect a low-scoring draw between these rivals.
Go for a draw in the Moneyline. If you bet $100 at +238, you will gain $238 for a total payout of $338.
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