Serie A Matchday 20 Betting Favorites

Last Updated on January 8, 2026 4:26 pm by Erwin Noguera

Serie A has been delivering great excitement and a tight race this season, and Matchday 20 will feature another marquee clash.

League leaders Inter will face a very tough test when they host Napoli, who sit third, four points behind.Milan, currently second, will be keeping a close eye on that match as they travel to face a Fiorentina side that has started to pick up wins again.

Juventus have enjoyed a run of positive results and have closed the gap at the top, and they will have another chance to climb the table when they take on Cremonese, while Roma will be looking to avoid dropping points as they host Sassuolo.

At Gambyl Exchange, you can explore all the predictions for the Italian Serie A, the final bets for this matchday, and the odds for each match.

Serie A Weekly Pick Betting Odds

Serie A Matchday 20: Roma vs. Sassuolo

Roma have fallen slightly off the pace at the top, but remain firmly in the race. With 36 points, they sit fifth, just six points behind the leaders, although having played one more match than those above them. They are coming off a 2–0 away win over Lecce and will be looking to record back-to-back victories for the first time since November. Alongside Inter, they are the only team yet to draw a match this season. Gian Piero Gasperini is dealing with 10 absences due to injuries, suspensions, and the Africa Cup of Nations, with Pellegrini, Dovbyk, and Cristante among the names missing.

Sassuolo, meanwhile, are in 11th place with 23 points after six wins, five draws, and eight defeats, having scored 23 goals and conceded 25.Interestingly, they have performed better away from home, collecting 12 of their 27 points on the road. They are currently out of form, having gone five matches without a win, losing two and securing just one victory in their last eight outings.

Roma vs. Sassuolo Betting Pick: Roma

Serie A Matchday 20: Fiorentina vs. Milan

Fiorentina have finally emerged from their dreadful run of form. They spent most of the season rooted to the bottom of the table until picking up their first win on December 21. They then lost to Parma, bounced back with a 1–0 victory over Cremonese, and most recently drew 2–2 with Lazio after conceding a penalty goal in the 90+5 minute. With 13 points, they sit in 18th place, four points behind Lecce and still with a chance to escape the relegation zone. Among the injured players is Edin Džeko, who has yet to score a league goal this season.

Milan suffered a setback in their title ambitions, though it could have been worse. On Thursday, they salvaged a 1–1 home draw against Genoa thanks to a Rafael Leão goal in the 90+2 minute, and the visitors missed a penalty in the last play, leaving them second in the table, three points behind their archrivals Inter. They have just one defeat all season, which came on opening day at home against Cremonese. That means they remain unbeaten away from home, with five wins and three draws. Christian Pulisic is the team’s top scorer with eight goals.

Fiorentina vs. Milan Betting Pick: Draw

Serie A Matchday 20: Inter vs. Napoli

Inter sits at the top of the table with 42 points. They have recorded 14 wins and four losses, and along with Roma are the only teams yet to draw a match this season. With 40 goals scored, they boast the league’s best attack, and Lautaro Martínez leads the scoring charts with 10 goals. They are coming off a 2–0 away win over Parma and are on a six-game winning streak in league play, although during that stretch they were eliminated on penalties by Bologna in the Italian Supercup semifinals and suffered a home defeat to Liverpool in the Champions League.

Napoli, meanwhile, missed a huge chance to stay in full control of their destiny after drawing 2–2 at home against Verona. They now sit third in the league with 38 points, four behind Inter. The Neapolitans have 12 wins, two draws, and four defeats, scoring 28 goals and conceding 15. Before that draw, they had won four straight matches, including two in the Italian Supercup, where they were crowned champions on December 22. The bad news for Antonio Conte is the long injury list, with Kevin De Bruyne, Romelu Lukaku, David Neres, Frank Anguissa, and Billy Gilmour all sidelined.

Inter vs. Napoli Betting Pick: Inter

Serie A Matchday 20: Juventus vs. Cremonese

Juventus have been climbing up the standings and are now in fourth place with 36 points, six behind Inter, but having played one more match.They have recorded 10 wins, six draws, and three losses, scoring 27 goals and conceding 16—more than any of the other teams in the top six. They are coming off a 3–0 away victory over Sassuolo and are unbeaten in five matches, winning four of them. At home, they remain undefeated with five wins and four draws, the most recent being a 1–1 draw against Lecce.

Cremonese are comfortably clear of the relegation zone. With 22 points, they sit in 13th place after five wins, seven draws, and seven defeats, having scored 20 goals and conceded 23. They started the season well, but that proved to be something of a mirage. They are currently on a five-match winless run, losing three of those games. Away from home, however, they have performed better, collecting 12 of their 30 points on the road.

Juventus vs. Cremonese Betting Pick: Juventus