Serie A Matchday 6 Betting Favorites

Last Updated on October 1, 2025 11:10 am by Erwin Noguera

Matchday 6 in Serie A promises a weekend full of high-stakes battles and early title implications. Milan, Juventus, Inter, Roma, and Napoli are all in the mix, and any slip can shift the balance at the top.

Milan, Napoli, and Roma are currently tied at the top of the table with four wins and one loss each. Juventus is in fourth place, while Atalanta and Cremonese occupy the sixth and seventh spots, respectively. Both teams remain unbeaten. Inter, sitting in fifth place, is on a do-or-die run with three wins and two losses.

As we look ahead to the upcoming matches on this sixth matchday, we expect some of the top teams to start separating themselves from the pack. The excitement continues in this entertaining league as teams vie for position.

At Gambyl Exchange, you can explore all the predictions for the Italian Serie A, the final bets for this matchday, and the odds for each match.

Serie A Weekly Pick Betting Odds

Serie A Matchday 6: Inter vs. Cremonese

Inter have one of the strongest home records in Serie A and rarely slip against newly promoted opposition. Their attack typically overwhelms defensively compact teams.

Cremonese may not have the talent Inter boasts, but they do possess resilience. They’ve shown defensive discipline and tend to keep matches tighter than expected.

There’s no doubt Inter are clear favorites, especially at home. The only real debate is by how much they will win. Cremonese may stay compact early, but Inter’s quality should eventually break them down.

Inter vs. Cremonese Betting Pick: Inter

Serie A Matchday 6: Fiorentina vs. Roma

Fiorentina remains unbeaten in their campaign, and we believe they will be a tough opponent to beat at home. Their offense has been effective in recent matches, consistently breaking down their opponents.

However, they have been quite active and may need to rotate players to prevent fatigue, which could impact their performance. Meanwhile, Roma has started to find some consistency, with an improved defense.

We expect the clash to be competitive, but we think the hosts will ultimately secure the three points.

Fiorentina vs. Roma Betting Pick: Fiorentina

Serie A Matchday 6: Napoli vs. Genoa

There may not be much to discuss regarding this match. We have a strong Napoli team currently on a run of 4 wins and one loss. They are eager to return to winning form and maintain their position at the top of the standings.

On the other hand, with only two goals scored and 7 conceded so far this season, it’s hard to see how Genoa can cope against a team that is tied for the second-most goals scored in the league. Therefore, our betting pick is clearly in favor of the hosts.

Napoli vs. Genoa Betting Pick: Napoli

Serie A Matchday 6: Juventus vs. Milan

This matchday promises to feature an intriguing clash between Juventus, which is currently unbeaten, and Milan, which, despite not being undefeated, is on a four-match winning streak and looking strong.

Juventus has a slight advantage as the host team, but we believe that won’t be sufficient to overpower Milan. However, we also don’t anticipate Milan dominating the match. We predict that both teams will exchange chances, leading to a low-scoring draw by the end of the game.

Juventus vs. Milan Betting Pick: Draw