Colts vs. 49ers For MNF Betting Odds and Free Pick

Last Updated on diciembre 19, 2025 12:50 pm by Erwin Noguera

NFL Week 16 wraps up with Monday Night Football, featuring the Indianapolis Colts and the San Francisco 49ers, two teams looking to move closer to a playoff berth.

The Colts, with Phillip Rivers, are in a rough stretch and are coming off an 18–16 loss to the Seattle Seahawks, despite not allowing a single touchdown.

The 49ers, meanwhile, are riding some momentum after a 37–24 victory over the Tennessee Titans, though they continue to battle in a very tough division.

En Gambyl Exchange, you can explore all NFL predictions, the final bets for this Matchday, and the odds for each match.

Indianapolis Colts vs. San Francisco 49ers Betting Odds and Info

¿Por qué apostar por los Colts?

The Indianapolis Colts were having a strong season, but things have unraveled in recent weeks. For now, they find themselves outside the playoff picture. They have lost four straight games and five of their last six, dropping to an 8–6 record and falling to third place in the division and eighth in the conference.

Their most recent game came against the Seattle Seahawks, where they lost 18–16 despite not allowing a single touchdown. All of the scoring came via field goals, six in total. However, the game was marked by the return of Phillip Rivers. The 44-year-old quarterback had been retired and had not played since January 9, 2021.

Rivers, who was brought in due to injuries to Daniel Jones, Anthony Richardson, and Riley Leonard, was signed on an emergency basis, took a physical the next day, and was added to the roster. The high school teacher became the second grandfather to play in the NFL, after Brett Favre did so in 2010, and is currently the oldest active player in the league.

Against the Seahawks, Rivers completed 18 of 27 passes for 120 yards, with one touchdown pass and one interception. Head coach Shane Steichen confirmed that Rivers will remain the starter, although Richardson is nearing his return.

Jonathan Taylor carried the ball 25 times for 87 yards. The running back continues to lead the league in rushing yards (1,443), carries (272), and rushing touchdowns (16).

¿Por qué apostar por los 49ers?

The San Francisco 49ers are firmly in the fight for a postseason spot.With a 10–4 record, they sit third in the NFC West behind the Los Angeles Rams and the Seattle Seahawks, both at 11–3. However, their strong overall numbers place them sixth in the conference, holding a two-game cushion over the Detroit Lions in the playoff race.

They are in excellent form, having won four straight games and five of their last six. Their most recent victory came against the Tennessee Titans, whom they defeated 37–24. It was a strong night for Brock Purdy, who completed 23 of 30 passes for 295 yards, threw three touchdown passes, and did not record an interception.

Jauan Jennings scored twice and has now found the end zone in three consecutive games, while tight end George Kittle added another touchdown. Christian McCaffrey also contributed with a rushing score and has now scored in four straight games, totaling six touchdowns over that span.

Defensively, the 49ers did not record any interceptions or sacks, two areas where the team has struggled. They rank last in the NFL in sacks (16) and have forced just five interceptions, ahead of only the New York Jets, who have yet to record one.

Análisis final de apuestas: Colts vs. 49ers

These two teams are experiencing completely different moments, with the Colts in a slump and the 49ers riding a positive run. Having to rely on a retired veteran significantly hurts Indianapolis’ chances, and we believe they will lose at home, further distancing themselves from the postseason.

Los numeros en Gambyl Exchange list the 49ers as the favorites, with a Moneyline of -280, while the Colts are priced at +230.

The last time these two teams met was on October 24, 2021, when the Colts won 30–18 on the road. Indianapolis has won two straight meetings, and San Francisco has not beaten them since 2001.

Go for a win for the 49ers. If you bet $100 at -280, you will gain $36 for a total payout of $136.

Indianapolis Colts vs. San Francisco 49ers Betting Pick: 49ers