Buffalo Bills Betting Odds

Last Updated on September 9, 2025 2:27 pm by Allen

Team Overview

The Buffalo Bills enter the 2025 season as overwhelming AFC East favorites with championship aspirations. Coming off Josh Allen’s MVP campaign, Buffalo returns one of the NFL’s most complete rosters with exceptional continuity on both sides of the ball. The Bills have won five consecutive AFC East titles and project another dominant season with a 13-4 record. The franchise maintains its championship window with Allen at his peak and a supporting cast that includes emerging receiver Khalil Shakir and running back James Cook. Buffalo’s organizational stability under Sean McDermott provides the foundation for another deep playoff run.

Offensive Line Analysis

Buffalo boasts one of the NFL’s premier offensive line units, ranked 3rd by Pro Football Focus heading into 2025. The Bills achieved remarkable continuity by returning all five starting offensive linemen from 2024, a rarity in today’s NFL. This unit allowed the fewest sacks in the league and features Pro Bowl left tackle Dion Dawkins anchoring a cohesive group led by center Connor McGovern. The interior line provides exceptional pass protection for Allen while creating consistent running lanes. The addition of Dan Feeney adds valuable depth to maintain this elite level of play. This offensive line stability is crucial to Buffalo’s championship aspirations and Allen’s continued MVP-level performance.

Defensive Line Strategy and Offensive Adjustments

The Bills significantly upgraded their pass rush by signing Joey Bosa, adding a proven edge rusher to complement their existing talent. Buffalo’s defensive line underwent a notable overhaul as the organization prioritized strengthening this unit after previous playoff disappointments. The addition of Bosa provides the consistent pressure the Bills lacked in crucial moments, while the interior defensive line maintains its run-stopping capabilities. This upgraded defensive front is expected to generate more quarterback hits and create favorable situations for Buffalo’s secondary. The combination of Bosa’s veteran presence and the Bills’ young defensive linemen creates a formidable unit capable of dominating opposing offensive lines.

2025 NFL Games

First Kickoff Game – vs. Baltimore Ravens

The Buffalo Bills pulled off a stunning 41-40 victory over the Baltimore Ravens, rallying from a 15-point deficit in the last four minutes and sealing the win with Matt Prater’s walk-off 32-yard field goal. Josh Allen led Buffalo with 394 passing yards, four total touchdowns, and orchestrated three scoring drives late, while Lamar Jackson and Derrick Henry starred for Baltimore, with Henry rushing for 169 yards and two touchdowns before a costly fumble.

Key moments included Allen’s two late rushing touchdowns, Keon Coleman’s critical touchdown catch on fourth down, and Henry’s turnover that helped swing the game. Jackson played through a minor injury but finished strong, while Prater, signed after Tyler Bass’s injury, delivered in the clutch. No major new injuries were reported from either side.

The Bills look poised for a strong season, displaying resilience and versatility, while the Ravens will focus on tightening defensive play and ball security ahead of next week.

Odds to Win Division and Super Bowl

Buffalo enters as heavy AFC East favorites at -330 odds, reflecting their overwhelming divisional dominance. The Bills’ Super Bowl odds sit at +700, making them among the top championship contenders. These odds reflect Buffalo’s combination of elite quarterback play, strong roster construction, and organizational stability. The Bills are positioned as the second-favorite behind Kansas City for AFC Championship honors, with many analysts viewing them as the primary threat to the Chiefs’ dominance.

2025 Predictions

Buffalo projects to win 13-4 and capture their sixth consecutive AFC East title. The Bills are expected to secure the #2 seed in the AFC playoffs and make another deep postseason run. Josh Allen is predicted to throw for over 4,250 yards with 33 touchdowns while maintaining his dual-threat capabilities. The defense, bolstered by Joey Bosa’s addition, should rank among the top 10 units in the NFL. Buffalo is widely predicted to reach the AFC Championship Game with legitimate Super Bowl aspirations in what many consider their best championship opportunity since their early 1990s run.