Kansas City Chiefs Betting Odds

Last Updated on September 10, 2025 9:22 am by Allen

Team Overview

The Kansas City Chiefs enter 2025/2026 seeking their 10th consecutive AFC West title with Patrick Mahomes leading a retooled roster. Kansas City faces shorter championship odds than previous years but remains the division favorite at -118, reflecting increased competition within the AFC West. The Chiefs lost key veterans including guard Joe Thuney to Chicago and receiver DeAndre Hopkins to Baltimore, requiring adjustments to their championship formula. Mahomes promises a more aggressive downfield passing attack after 2024’s conservative approach limited big-play opportunities. The Chiefs project a 12-5 record as they pursue another Super Bowl appearance.

Offensive Line Analysis

Kansas City faces significant questions on the offensive line after losing veteran guard Joe Thuney to free agency. Rookie first-round pick Josh Simmons steps into the left tackle role alongside second-year guard Kingsley Suamataia, creating a new left side of the line. The Chiefs allowed 36 sacks in 2024, Mahomes’ highest total in his career, leading to the offseason changes. The effectiveness of the offensive line will determine Mahomes’ ability to implement his promised aggressive downfield passing attack. Kansas City added depth with Jaylon Moore while expecting internal development from young players.

Defensive Line Analysis

The Chiefs strengthened their defensive line by adding Jerry Tillery for interior pass rush depth while maintaining edge rushers Chris Jones and George Karlaftis. Kansas City’s defensive front provides the foundation for a unit that must compensate for offensive line questions. The defensive line showed improvement in generating pressure during 2024’s championship run, and the addition of Tillery should provide more consistent interior disruption. The Chiefs’ defense relies heavily on this unit’s ability to create third-and-long situations for their secondary to exploit.

2025 NFL Season Preview

First Kickoff Game – vs. Los Angeles Chargers

Kansas City opens in Brazil against Los Angeles Chargers on Friday, September 6, marking the NFL’s first regular season game in South America. The Chiefs fell 27–21 to the Chargers, with Patrick Mahomes passing for 258 yards and scoring both through the air and on the ground. Despite a late push, the Chiefs couldn’t overcome early missed opportunities and turnovers.

Rookie receiver Xavier Worthy was sidelined after a collision and right shoulder injury, compounding issues for a depleted receiving corps already missing Rashee Rice and Jalen Royals. The defense also struggled with penalties and couldn’t contain Justin Herbert, who threw three touchdowns.

The Chiefs look to regroup for a September 14 home opener against the Philadelphia Eagles, aiming to clean up execution and improve receiver depth against an elite secondary.

Odds to Win Division and Super Bowl

Kansas City maintains -118 odds to win the AFC West, their shortest divisional odds in years due to improved competition. The Chiefs’ Super Bowl odds stand at +750, reflecting their continued status as championship favorites despite roster changes. These odds acknowledge Kansas City’s championship pedigree while recognizing the challenges posed by Denver’s improvement and division-wide competitive balance. The Chiefs remain the AFC’s gold standard despite questions about their supporting cast.

2025 Predictions

The Chiefs project a 12-5 record and AFC West title, though with less margin for error than previous seasons. Mahomes is predicted to return to more aggressive downfield passing, potentially reaching career-high yardage totals with improved deep ball accuracy. The defense should maintain top-10 ranking while the offensive line’s development determines the ceiling for Kansas City’s championship aspirations. The Chiefs are predicted to reach the AFC Championship Game with potential for another Super Bowl appearance if their offensive line improvements prove effective.