Kansas City Chiefs Betting Odds

Last Updated on October 7, 2025 2:07 pm by Allen

Team Overview

The Kansas City Chiefs enter 2025/2026 seeking their 10th consecutive AFC West title with Patrick Mahomes leading a retooled roster. Kansas City faces shorter championship odds than previous years but remains the division favorite at -118, reflecting increased competition within the AFC West. The Chiefs lost key veterans including guard Joe Thuney to Chicago and receiver DeAndre Hopkins to Baltimore, requiring adjustments to their championship formula. Mahomes promises a more aggressive downfield passing attack after 2024’s conservative approach limited big-play opportunities. The Chiefs project a 12-5 record as they pursue another Super Bowl appearance.

Offensive Line Analysis

Kansas City faces significant questions on the offensive line after losing veteran guard Joe Thuney to free agency. Rookie first-round pick Josh Simmons steps into the left tackle role alongside second-year guard Kingsley Suamataia, creating a new left side of the line. The Chiefs allowed 36 sacks in 2024, Mahomes’ highest total in his career, leading to the offseason changes. The effectiveness of the offensive line will determine Mahomes’ ability to implement his promised aggressive downfield passing attack. Kansas City added depth with Jaylon Moore while expecting internal development from young players.

Defensive Line Analysis

The Chiefs strengthened their defensive line by adding Jerry Tillery for interior pass rush depth while maintaining edge rushers Chris Jones and George Karlaftis. Kansas City’s defensive front provides the foundation for a unit that must compensate for offensive line questions. The defensive line showed improvement in generating pressure during 2024’s championship run, and the addition of Tillery should provide more consistent interior disruption. The Chiefs’ defense relies heavily on this unit’s ability to create third-and-long situations for their secondary to exploit.

2025 NFL Season Preview

First Kickoff Game – vs. Los Angeles Chargers

Kansas City opens in Brazil against Los Angeles Chargers on Friday, September 6, marking the NFL’s first regular season game in South America. The Chiefs fell 27–21 to the Chargers, with Patrick Mahomes passing for 258 yards and scoring both through the air and on the ground. Despite a late push, the Chiefs couldn’t overcome early missed opportunities and turnovers.

Rookie receiver Xavier Worthy was sidelined after a collision and right shoulder injury, compounding issues for a depleted receiving corps already missing Rashee Rice and Jalen Royals. The defense also struggled with penalties and couldn’t contain Justin Herbert, who threw three touchdowns.

The Chiefs look to regroup for a September 14 home opener against the Philadelphia Eagles, aiming to clean up execution and improve receiver depth against an elite secondary.

Week 2 vs. Philadelphia Eagles

The defending champions suffered their second consecutive loss, falling to 0-2 for the first time since 2014. Patrick Mahomes threw for 187 yards and rushed for 66 yards with a touchdown, but Travis Kelce’s dropped touchdown that became an interception proved decisive. The Eagles’ defense dominated throughout, limiting Kansas City’s explosive plays and forcing crucial turnovers. Andy Reid’s aggressive fourth-down decisions backfired, and the Chiefs’ offensive struggles without key receivers became more apparent.

Week 3 vs. New York Giants

The Kansas City Chiefs bounced back from their poor start with a convincing 22-9 victory over the New York Giants on Sunday Night Football, earning their first win of the 2025 season and avoiding a dreaded 0-3 start. Patrick Mahomes completed 22 of 37 passes for 224 yards and a touchdown to Tyquan Thornton, while also making a crucial momentum-shifting play by recovering his own backward pass from defender Bobby Okereke’s hands. The Chiefs defense dominated the Giants’ receiving corps, holding star rookie Malik Nabers to just two catches for 13 yards despite being targeted seven times. Isiah Pacheco led the ground game with 45 yards on 10 carries as Kansas City controlled the line of scrimmage.

While the victory was essential to prevent an unprecedented 0-3 start to the Mahomes era, the Chiefs still face significant challenges in catching up to the 3-0 Chargers in the AFC West. Despite the struggles through three weeks, Andy Reid’s team showed signs of their championship DNA by responding to adversity and finding ways to win ugly games. The Chiefs will host Baltimore Ravens next week in what could be a pivotal early-season matchup as they attempt to string together consecutive victories and regain their championship form.

Week 4 vs. Baltimore Ravens

The Chiefs delivered a statement victory, demolishing the Baltimore Ravens 37-20 at Arrowhead Stadium in their most complete performance of the season. Patrick Mahomes threw for 270 yards and 4 touchdowns without an interception, earning AFC Offensive Player of the Week honors. The return of Xavier Worthy (shoulder) provided an immediate impact, as he recorded 5 receptions for 83 yards while also contributing 38 rushing yards on two carries. The Chiefs’ defense dominated, sacking Lamar Jackson three times and forcing him to exit the game in the third quarter with a hamstring injury.

Kansas City’s resurgence, combined with the Chargers’ surprising loss, has dramatically shifted the AFC West race, with the Chiefs now at 35% to win the division compared to just 23% entering Week 4. They travel to Jacksonville for Monday Night Football in Week 5, looking to build on their momentum.

Week 5 vs. Jacksonville Jaguars

The Chiefs dropped a nail-biter 31-28 to the Jacksonville Jaguars, as Patrick Mahomes passed for 476 yards and four touchdowns but was unable to overcome costly mistakes, including a 99-yard pick-six and a lost fumble. Penalties and special teams errors plagued the team, and injuries to receiver Xavier Worthy affected their offensive rhythm in key moments.

Kansas City’s next test comes against the Las Vegas Raiders, where the team aims to tighten fundamentals, manage penalties, and restore momentum in the AFC West race.

Odds to Win Division and Super Bowl

Kansas City maintains -118 odds to win the AFC West, their shortest divisional odds in years due to improved competition. The Chiefs’ Super Bowl odds stand at +750, reflecting their continued status as championship favorites despite roster changes. These odds acknowledge Kansas City’s championship pedigree while recognizing the challenges posed by Denver’s improvement and division-wide competitive balance. The Chiefs remain the AFC’s gold standard despite questions about their supporting cast.

2025 Predictions

The Chiefs project a 12-5 record and AFC West title, though with less margin for error than previous seasons. Mahomes is predicted to return to more aggressive downfield passing, potentially reaching career-high yardage totals with improved deep ball accuracy. The defense should maintain top-10 ranking while the offensive line’s development determines the ceiling for Kansas City’s championship aspirations. The Chiefs are predicted to reach the AFC Championship Game with potential for another Super Bowl appearance if their offensive line improvements prove effective.