San Francisco 49ers Betting Odds

San Francisco 49ers Betting Odds

Last Updated on September 9, 2025 6:04 am by Henry

Team Overview

The San Francisco 49ers look to bounce back after a 6-11 collapse in 2024. With Brock Purdy still leading the offense, Kyle Shanahan’s squad is healthy and refocused. A favorable schedule makes them divisional favorites.

Offensive Line Analysis

The O-line remains a concern, but returning starters add continuity. Rookie depth will need to step up.

Defensive Line Analysis

The 49ers’ defensive line is strong, but offseason departures raise questions about depth. Nick Bosa remains the star centerpiece.

Week 1 – vs. Seattle Seahawks

Result & Key Stats
The San Francisco 49ers earned a 21–17 road win. QB Brock Purdy threw for 214 yards with 1 TD and 2 INTs, bouncing back in the clutch. The defense held Seattle to just 289 total yards while forcing two turnovers.

Key Moments & Injuries
Purdy connected with TE Jake Tonges for the go-ahead fourth-quarter touchdown. DE Nick Bosa applied relentless pressure—registering a sack and two QB hits. TE George Kittle exited early with a minor groin issue and remains questionable for Week 2.

Looking Ahead
San Francisco travels to face the New Orleans Saints next. Ball security from Purdy and Kittle’s health will be key to sustaining momentum.

Odds to Win Division & Super Bowl

  • Division Odds: +160
  • Super Bowl Odds: Top-5 contender at +1200

Predictions

The 49ers should reclaim the NFC West title. Predicted record: 11-6, playoff berth expected.

NFL Schedule and Picks Weeks 1 through 18

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