San Francisco 49ers Betting Odds

Last Updated on September 28, 2026 8:08 am by Henry

Team Overview

The San Francisco 49ers went 12-5 last season and still finished third in the NFC West. That tells you how brutal this division has become. San Francisco entered Week 18 with the division and home field on the line, then lost to Seattle. It then lost to Seattle again in the divisional round, this time by 35 points. Injuries explain most of it. Nick Bosa, Fred Warner, George Kittle and Brock Purdy all missed significant time. As a result, the pass rush collapsed to 20 sacks, the fewest in the NFL.

John Lynch responded by adding rather than rebuilding. Mike Evans arrived with 11 straight 1,000-yard seasons from 2014 to 2024, which tied Jerry Rice’s NFL record. Christian Kirk also joins him in a rebuilt receiver room. Meanwhile, Dre Greenlaw returned, Nate Hobbs signed at corner, and San Francisco traded for defensive tackle Osa Odighizuwa. Raheem Morris takes over as defensive coordinator. Kyle Shanahan is entering his tenth season, which ties Bill Walsh for the longest coaching tenure in franchise history. He is also back on the sideline after a July 14 car crash. The crash left him with a concussion, a broken nose, three broken ribs and a broken hand.

Offensive Line Analysis

Continuity is the story here. San Francisco returns all five starters, which is rare in the modern league. It is also particularly valuable in a Shanahan run scheme that depends on timing between linemen. Trent Williams remains one of the best tackles in football, landing at No. 40 on the NFL’s Top 100 list. Jake Brendel, meanwhile, holds down the middle. Chris Foerster has coached this group for years, and he stepped into head coaching duties during Shanahan’s recovery without disruption. The concern is age at the top rather than talent or depth. Keeping Williams upright for a full season has become an annual question. In fact, the offense looks materially different when he is out. So far, though, the results are excellent: Purdy has not been sacked through two games.

Defensive Line Analysis

Twenty sacks. That number, the lowest in the NFL, is the entire reason this offseason looked the way it did. Bosa missed most of the year, and the front had nothing behind him. As a result, San Francisco finished last in the league in sack rate. Odighizuwa arrived via trade to strengthen the interior. The 49ers also used third and fourth-round picks on edge rusher Romello Height and defensive tackle Gracen Halton. Halton has been one of the most disruptive interior rushers in camp. That depth matters more than expected, because Alfred Collins tore his patellar tendon at a practice in Melbourne. He will miss the season. Morris has talked about more versatility in the front, and Lynch was blunt that everything starts up front. The early numbers show the swing. The front had no sacks in Melbourne, then recorded four against Miami, including one from Bosa. A healthy Bosa fixes most of this on his own.

2026 NFL Season

Week 1

49ers vs Los Angeles Rams | Thursday, September 10 | 8:35 PM ET | Melbourne Cricket Ground, Melbourne, Australia

San Francisco opens the season in the NFL’s first regular-season game in Australia. The Rams are the designated home team at a neutral site. The 49ers opened at +2.5 with a moneyline of +124 against Los Angeles at -148 and a total of 48.5. Since then, the spread has firmed toward three points. Both teams finished 12-5 last season, and Seattle knocked out both of them.

The matchup history favors San Francisco more than the number suggests. Mac Jones started both meetings against the Rams last season. Even so, the 49ers moved the ball efficiently through the air, posting a positive EPA per play in Week 5. That came against a secondary the Rams have since rebuilt around Trent McDuffie. Purdy is a clear upgrade on Jones. The question is whether a pass rush that produced 20 sacks all of last season can pressure Matthew Stafford. If not, Stafford will find Puka Nacua.

Week 1 Recap

San Francisco opened the season with a 27-7 win over the Los Angeles Rams at the Melbourne Cricket Ground. It was the NFL’s first regular-season game in Australia, and more than 100,000 fans packed the stadium. The 49ers trailed 7-3 early in the second quarter. Then they scored 24 unanswered points. Brock Purdy was efficient all night, completing 25 of 34 for 205 yards and three touchdowns. He posted a 105.6 rating, and the Rams did not sack him once.

The three scoring passes went to three different targets. First came a 39-yarder to Demarcus Robinson. Then Mike Evans caught a two-yard score in his 49ers debut, and Deebo Samuel added a 15-yard touchdown. The run game did the rest, piling up 174 yards on 30 carries at 5.8 a pop. It also did not lose a single yard on the ground. San Francisco held the ball for nearly 34 minutes and committed only two penalties for 21 yards. Overall, it was a remarkably clean performance.

The defense never recorded a sack but still made Matthew Stafford uncomfortable. It charted eight quarterback hits and eight knockdowns. It also forced an interception, recovered a fumble and stopped Los Angeles twice on fourth down. The cost, however, was steep. Alfred Collins tore his patellar tendon at a practice in Melbourne and will miss the season. That thinned an interior that was already the offseason priority. Two days later, Kyle Shanahan signed a multiyear extension.

Week 2

Dolphins at San Francisco 49ers | Sunday, September 20 | 4:25 PM ET | Levi’s Stadium, Santa Clara, CA

San Francisco opens as the largest favorite on the entire Week 2 board. The 49ers sit at -950 on the moneyline against the Miami Dolphins at +625. The spread is 12.5 points, and the total is 46.5. Miami arrives at 0-1 after a 27-13 loss in Las Vegas. Meanwhile, San Francisco returns home from Australia with a few extra days of rest.

A number this wide leaves no margin for a flat performance, and that is the entire risk here. San Francisco just went through a 15-hour flight, a Thursday game and a 15-hour flight back. That kind of travel often shows up the following week. The 49ers also must cover 12.5 points with a pass rush that went sackless in Week 1. On top of that, they just lost Collins for the season. What favors them is the matchup. Miami’s offense managed 13 points against a Raiders defense that finished last season in the bottom half of the league. Meanwhile, Brock Purdy is coming off a game in which the Rams never sacked him.

Week 2 Recap

San Francisco came home from Australia and beat the Miami Dolphins 35-13. No 49ers team had ever opened a season with back-to-back wins by at least 20 points. The 49ers scored touchdowns on each of their first five drives. They led 35-6 before Miami added a late touchdown on a 77-yard catch-and-run.

Brock Purdy was close to perfect. He completed 20 of 22 passes for 287 yards and two touchdowns, a 149.1 rating. At one point, he hit 18 passes in a row. He also added a two-yard touchdown run. His 12-yard score to George Kittle was Kittle’s first touchdown since tearing his Achilles in January. Kyle Juszczyk caught the other one. Meanwhile, Christian McCaffrey ran for two one-yard touchdowns and reached 100 for his career. Only three players in the Super Bowl era got there faster. Miami did not sack Purdy once.

Defensively, the 49ers recorded four sacks, including one from Nick Bosa. That came after a Week 1 in which the pass rush failed to register any. For this team, that is the number that matters most. The one loss came at receiver. Demarcus Robinson left in the second quarter with an ankle injury.

Week 3

Cardinals at San Francisco 49ers | Sunday, September 27 | 4:05 PM ET | Levi’s Stadium, Santa Clara, CA

San Francisco opens as an 8.5-point home favorite against the Arizona Cardinals. DraftKings priced the 49ers at -455 on the moneyline, with Arizona at +350 and the total at 47.5. San Francisco continues a three-game home stand. It has also outscored its first two opponents 62-20.

Big numbers have already burned one favorite against this opponent. Arizona won outright as an 11.5-point underdog in Week 1 by holding the ball for 37 minutes. Then again, Seattle beat the same team by 24 a week later and held it to 151 yards. Purdy has not been sacked in two games. The Cardinals may also be short at cornerback, because Will Johnson and Max Melton both left the Seattle game. The main risk for San Francisco is a slow start that lets Arizona shorten the game.

Week 3 Recap

San Francisco survived Arizona 36-30 at Levi’s Stadium, improving to 3-0. Before halftime, a trick play produced the signature moment. Brock Purdy hit Mike Evans, who lateralled to Deebo Samuel Sr. for an 80-yard score. As a result, Samuel finished with zero catches for 80 yards and a touchdown.

Purdy completed 15 of 27 passes for 297 yards and four touchdowns. Moreover, he took no sacks at all. Christian McCaffrey ran 15 times for 75 yards and a score. Meanwhile, George Kittle caught six passes for 82 yards and two touchdowns. The 49ers averaged 8.7 yards per play on just 50 snaps.

Defensively, San Francisco managed two sacks without Nick Bosa, who is nursing a calf strain. Fred Warner also posted a career-high 17 tackles. Even so, Arizona controlled the ball for nearly 39 minutes. At 3-0, the 49ers stand alone atop the NFC West. However, Evans left on a cart with a rib or oblique injury. The starting left tackle also departed with a stinger.

Week 4

Denver Broncos at San Francisco 49ers | Sunday, October 4 | 4:25 PM ET | Levi’s Stadium, Santa Clara, CA

Denver arrives at 2-1, fresh off a Sunday night comeback against the Rams. The Broncos trailed 16-0 at halftime, then scored all 30 of their points afterwards. Bo Nix threw two touchdown passes and then ran in the winner from a yard out. Meanwhile, a 66-yard interception return for a score swung the momentum. Their lead back, though, managed just 49 yards on 17 carries.

San Francisco is a 2.5-point home favorite, with the total at 45.5. That is a modest price, though, for an unbeaten home team. If Bosa sits again, the 49ers must find pressure elsewhere. Still, Purdy has been exceptional, and Kittle keeps producing down the seams. Because Denver just erased a 16-point deficit, nobody should expect a blowout. Health, not form, is the variable here.

Odds to Win Division and Super Bowl

Odds to Win NFC West: +300

Odds to Win Super Bowl: +1800

Predictions

Overall Record: The 49ers project to finish around 11-6, in a division where that may not be enough

Playoff Chances: Strong, though more likely through a wild card than a division title

Super Bowl Chances: A genuine contender priced outside the top tier, with real upside if the front stays healthy

San Francisco has the most talent of any third-place team in football. Purdy won six of his final seven starts after returning from turf toe last season. McCaffrey was Comeback Player of the Year on a league-high 450 touches. The receiver room also went from thin to deep in one offseason. What held this team back was the defense. Last year it was below average per play against both the run and the pass. Its sack rate was the worst in the league, and its interception rate was second-worst. Better health should fix a lot of that, and the four sacks against Miami were a good start. The 49ers have already handled Los Angeles, so the real proof comes against Seattle.