Arizona Cardinals Betting Odds

Last Updated on October 28, 2025 10:42 am by Henry

Team Overview

The Arizona Cardinals continue their rebuild around Kyler Murray. New defensive coaching staff and a developing offensive unit headline their 2025 hopes. The Cardinals are improving but still seen as underdogs.

Offensive Line Analysis

Young players are being developed, but protection remains an issue. Rookie tackles may be forced into big roles early.

Defensive Line Analysis (2025)

Arizona’s D-line remains thin, but offseason signings provide rotational depth. Run defense is the main weakness.

Week 1 – vs. New Orleans Saints

Result & Key Stats
The Arizona Cardinals opened with a 20–13 road win. QB Kyler Murray threw for 188 yards and 2 TDs, spreading the ball effectively. The defense held New Orleans to just 4.7 yards per play and forced critical red-zone stops.

Key Moments & Injuries
Murray connected with WR Marvin Harrison Jr. on a 24-yard TD to set the tone. In the fourth quarter, CB Sean Murphy-Bunting intercepted a pass to seal the victory. No major injuries were reported.

Looking Ahead
Arizona heads to face the Carolina Panthers in Week 2. Keeping Murray upright and integrating Harrison Jr. steadily into the offense will be key to maintaining momentum.

Week 2 – vs. Carolina Panthers

Result & Key Stats
The Arizona Cardinals edged Carolina 20–17 on the road. QB Kyler Murray threw for 214 yards and 2 TDs, including a late strike to WR Marvin Harrison Jr..

Key Moments & Injuries
Murray orchestrated the decisive fourth-quarter drive, capping it with Harrison Jr.’s TD. CB Sean Murphy-Bunting added another key interception. Arizona reported no major injuries.

Looking Ahead
The Arizona Cardinals face the Seattle Seahawks in Week 3, aiming to build on their 2–0 start.

Week 3 – vs. San Francisco 49ers

Result & Key Stats
The Arizona Cardinals fell 16–15 on the road after a late field goal. QB Kyler Murray kept the offense in striking distance against a stout 49ers defense. Arizona briefly grabbed a fourth-quarter lead before San Francisco answered at the buzzer.

Key Moments & Injuries
A late safety swung momentum to Arizona, but the 49ers converted a critical deep ball to Ricky Pearsall to set up the decisive score. No major Cardinals injuries were immediately reported. San Francisco 49ers

Looking Ahead
The Arizona Cardinals host the Seattle Seahawks in Week 4, emphasizing protection for Kyler Murray and finishing drives.

Week 4 – vs. Seattle Seahawks

Result & Key Stats
The Arizona Cardinals lost 23–20 at home, slipping to 2–2. QB Kyler Murray threw for 234 yards and 1 TD.

Key Moments & Injuries
The Cardinals tied the game in the 3rd quarter, but Seattle’s defense forced a late punt that set up the winning FG. WR Marvin Harrison Jr. led with 71 receiving yards.

Looking Ahead
The Cardinals host the Tennessee Titans in Week 5.

Week 5 – vs. Tennessee Titans

Result & Key Stats
The Arizona Cardinals dropped a heartbreaking 22–21 decision to the Titans, falling to 2–3 on the season. QB Kyler Murray completed 23 of 31 passes for 220 yards with no touchdowns or interceptions, but he absorbed three sacks. On the ground, Murray added 25 yards and a rushing score. RB Michael Carter contributed 51 rushing yards and 1 TD, while RB Bam Knight also punched in a short-yardage score.

Key Moments & Injuries
Arizona started fast with 21 first-half points, including a 71-yard burst from RB Emari Demercado, but turnovers derailed momentum. The Cardinals committed three costly fumbles, two of which directly set up Tennessee’s comeback. Rookie WR Marvin Harrison Jr. again showcased his elite talent, leading with 98 receiving yards. On defense, rookie safety Dadrion Taylor-Demerson impressed with an interception and two pass breakups, while DE Josh Sweat tallied two sacks. Injury-wise, CB Denzel Burke (knee) and WR Greg Dortch (collarbone) are questionable moving forward.

Looking Ahead
The Cardinals (2–3) head to Indianapolis in Week 6 to face the Colts (4–1). Therefore, ball security will be critical if Arizona hopes to upset one of the AFC’s hottest teams. Getting consistent production from Harrison Jr. and limiting turnovers will be top priorities.

Week 6 – vs. Indianapolis Colts

Result & Key Stats

The Arizona Cardinals came close to a comeback but fell 27–31 to the Colts in a hard-fought battle at home. QB Jacoby Brissett delivered a solid performance (27/44, 320 yards, 2 TD, 1 INT), keeping the Cardinals alive until the final quarter. Rookie TE Trey McBride shined again, hauling in 8 receptions for 72 yards and a touchdown, while WR Greg Dortch added another score through the air.

Key Moments & Injuries

Despite a balanced attack through the air, the run game couldn’t quite find rhythm, combining for just 88 yards led by Michael Carter and Bam Knight, who added a short rushing touchdown. On defense, LB Mack Wilson was everywhere with 9 tackles and an interception, while veteran Budda Baker anchored the secondary with key stops. Rookie CB Max Melton showed flashes before exiting due to a hamstring issue.

Looking Ahead

The Cardinals (2–4) will face the Green Bay Packers in Week 7. With Kyler Murray nearing a return from injury, Arizona’s offense could gain a major boost. If McBride and the young core can maintain their chemistry with Brissett or Murray under center, the Cardinals might be ready to turn the corner as they aim to climb back in the NFC West standings.

Week 7 – vs. Green Bay Packers

The Arizona Cardinals came up short in a tight 27–23 home loss to the Green Bay Packers despite an impressive showing from veteran quarterback Jacoby Brissett, who completed 25 of 36 passes for 279 yards and two touchdowns, earning a 110.7 passer rating. He displayed great accuracy and composure, connecting frequently with Trey McBride, who caught 10 passes for 74 yards and both scores, and rookie Marvin Harrison Jr., who added 58 yards on key deep routes.

On the ground, Bam Knight led the rushing effort with 57 yards, while Brissett contributed another 26 yards on scrambles, though his late fumble proved costly in the fourth quarter. Defensively, the Cardinals struggled to maintain pressure on Jordan Love, recording just one sack from Zaven Collins, but Akeem Davis-Gaither and Jalen Thompson combined for eight solo tackles and two tackles for loss to keep Arizona within striking distance.

Looking Ahead: Now 2–5, Arizona enters its Week 8 bye with several key players recovering from injury, including Kyler Murray (foot) and Emari Demercado (ankle). The Cardinals will use the extra week to regroup offensively and clean up protection issues before heading into a crucial divisional stretch that could define their season.

Week 8 – BYE WEEK

Odds to Win Division & Super Bowl

• Division Odds: +425
  
• Super Bowl Odds: +7000
  

Predictions

The Cardinals project to finish around 6-11, with Murray providing highlights but not enough support to contend for the division.